Neurogenic Detrusor Overactivity (NDO)

Neurogenic Detrusor Overactivity is defined by overactivity of the detrusor (bladder muscle) attributed to a relevant neurological disorder such as Multiple Sclerosis or spinal cord injury. Up to 80% of patients with multiple sclerosis (MS) or spinal cord injury (SCI) can suffer from urinary incontinence. Changes and damage to the nerves involved in bladder activity can lead to involuntary contractions of the detrusor muscle leading to urinary leaking, which can be distressing and socially isolating leading to a reduced QOL for sufferers.

Overactive bladder (OAB)

Overactive bladder is defined as Overactivity of the detrusor (bladder) muscle with no identifiable aetiology. This is a condition with bladder-storage function that causes a sudden urge to urinate. The urge may be difficult to stop, and overactive bladder may lead to the involuntary loss of urine (incontinence). The frequent need to urinate may occur during the day, at night (Nocturia), or both.

More than 40% of people with overactive bladder have incontinence and overactive bladder is estimated to occur in 7-27% of men and 9-43% of women. It becomes more common with age. Some studies suggest that the condition is more common in women, especially when associated with loss of bladder control. Most people with the condition have problems for years and will often self-manage due to embarrassment. This can lead to social isolation and limitations on work and social life.